Welcome to the GeneACT server. GeneACT is comprised of a series of bioinformatic tools that are designed to specifically characterize the regulatory regions of the genes of interest. The regulation of gene transcription is very important for understanding signal transduction networks.

News: GeneACT update

9/11/06 Added 8bp seed MicroRNA sequence (Lewis BP et al. Cell 2005) for visualization of microRNAs in PBSS.

1/13/06 Added MicroRNA function for DBSS. GeneACT is under construction and still being tested. Feedback, bugs and general comments/questions should be sent to Tom.Cheung@colorado.edu.

Potential Binding Site Search is a tool that allows the user to search for binding sites (user input or using the transcription factor database, TFD) in many genes in a high throughput way. Scalable Vector Graphic (SVG) viewer is provided for a better visualization of the gene structure in a transcription factors orientated way. To utilize the full function of promoter browser using SVG, PBSS should be used on windows platforms. more...

Genomic Sequence Retrieval is a tool that allows the user to retrieve genomic sequence. At present, only Homo sapiens, Mus musculus and Rattus norvegicus genomes are supported. more...

Differential Binding Site Search is a tool that allows the user to compare the frequencies of the binding sites that are found in two sets of genes (named regulated and control gene set hereafter). This tool is intended for users who have done some microarray experiments and would like to know what kind of binding sites (user input, TF binding sites or MicroRNA target sites) are enriched in their regulated gene set. more...

TFD Search allows the user to query our database for binding site sequence or transcription factor name of interest. TFD, the Transcription Factor Database, consists of >7000 binding sites from the literatures. In order to keep the database current, we also provide interface for binding site submission. The new binding sites will be curated and enter into the database for use by other tools.